Linked Life Data

2935109

Source:http://linkedlifedata.com/resource/pubmed/id/2935109

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1986-2-12
pubmed:abstractText
Nineteen patients with left ventricular hypertrophy were given intravenous calcium antagonists: 9 patients received intravenous verapamil (VPM IV) and 10 patients diltiazem (DTZ) by intracoronary and then intravenous injection. Systemic and pulmonary resistances, cardiac output, left ventricular and aortic pressures, isometric contractility, isometric relaxation and left ventricular compliance were studied in sinus rhythm, during atrial and then ventricular pacing at 120/min and finally after tachycardia before and after administration of calcium antagonists. Left ventriculography in the 30 degrees RAO projection in sinus rhythm was performed before and after injection of the calcium antagonists to study the variations in the end diastolic volume, mass and mass-volume ratio. Finally, frame by frame numerisation of the ventriculographies during systole and diastole helped evaluate variations in amplitude, time and velocity of fibre shortening or lengthening. The administration of the calcium antagonists did not have any significant effect on heart rate (-2.8 +/- 10 p. 100, NS) or indices of isometric contractility (delta Vmax + 4 +/- 43 p. 100, NS). Significant falls in systemic and pulmonary resistances (-15 +/- 23 p. 100, p less than 0.05 and - 26 +/- 32 p. 100, p less than 0.05, respectively) and an increase in systolic index (+ 15.5 p. 100 +/- 12 p. 100, p less than 0.01) were observed. The improvement in left ventricular ejection was independent of the variation in resistances but was closely related to variations of parameters of relaxation. The effects on volumic compliance and filling velocities were also closely related to variations in relaxation (p less than 0.05 and p less than 0.01). Calcium antagonists protected left ventricular ejection during supraventricular tachycardia and prevented the changes in left ventricular relaxation observed during arrhythmias and after tachycardia.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-9683
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1843-51
pubmed:dateRevised
2009-2-13
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Effects of injectable calcium blockers on cardiac function and relaxation in left ventricular hypertrophy].
pubmed:publicationType
Journal Article, English Abstract