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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1986-1-28
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pubmed:abstractText |
In vivo platelet activity was studied in 58 patients with AMI on admittance to the Coronary Care Unit, in 48 of these patients after 1 week, in 30 after 1 month and in 24 patients after 6 months. Patients were carefully selected and excluded if they had associated diseases known to increase platelet activity. In vivo activation was studied by evaluating the plasma concentration of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) in the same blood sample. On admittance (x = 58.5) and on day 7 (x = 52.9) beta-TG values were significantly higher than those obtained in the control group (x = 29). beta-TG values were moderately elevated after 1 month (x = 37.7) and then returned to values similar to those of the control group after 6 months (x = 27.9). The simultaneous assessment of PF4 shows a beta-TG/PF4 ratio indicative for in vitro release (less than or equal to 2.5) in many patients on days 1 and 7. Moreover, the beta-TG/PF4 ratio in patients with AMI tends towards 2 when beta-TG values are high. These results may indicate a greater tendency to an in vitro platelet release in the acute phase of AMI.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0340-6245
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
544-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2934859-Adult,
pubmed-meshheading:2934859-Aged,
pubmed-meshheading:2934859-Blood Platelets,
pubmed-meshheading:2934859-Cytoplasmic Granules,
pubmed-meshheading:2934859-Female,
pubmed-meshheading:2934859-Humans,
pubmed-meshheading:2934859-Male,
pubmed-meshheading:2934859-Middle Aged,
pubmed-meshheading:2934859-Myocardial Infarction,
pubmed-meshheading:2934859-Platelet Count,
pubmed-meshheading:2934859-Platelet Factor 4,
pubmed-meshheading:2934859-beta-Thromboglobulin
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pubmed:year |
1985
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pubmed:articleTitle |
Enhanced "in vitro" release of platelet alpha-granules after acute myocardial infarction (AMI).
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pubmed:publicationType |
Journal Article
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