rdf:type |
|
lifeskim:mentions |
umls-concept:C0003242,
umls-concept:C0024299,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0332293,
umls-concept:C0332448,
umls-concept:C0871261,
umls-concept:C1167395,
umls-concept:C1704632,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2911692
|
pubmed:issue |
6
|
pubmed:dateCreated |
1985-12-23
|
pubmed:abstractText |
To correlate treatment responses with numbers and types of "host cell infiltrates," lymphoid tissues from 10 patients with low-grade B cell malignancies were stained before, during, and after anti-idiotype therapy with a panel of monoclonal antibodies applied to frozen sections. Tissue penetration by the anti-idiotype antibodies was confirmed in five patients by these immunoperoxidase methods. Large numbers of phenotypic T helper cells were the main component of the "host infiltrate" in most patients. Two patients showed a complete and a near-complete clinical remission, four others had partial responses, and four did not respond to therapy. The two patients that developed clinical remission demonstrated the largest number of T cells, T helper cells, TAC+ cells, Leu-7+ cells, and in general the smallest number of proliferating cells as measured by the Ki-67 antibody. Other major differences in host cells were not evident among the patients. These preliminary data suggest that the type and amount of "host infiltrate" in low-grade B cell lymphomas may predict which patients will respond to anti-idiotype therapy.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Idiotypes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0022-1767
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
135
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4252-60
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2933460-Animals,
pubmed-meshheading:2933460-Antibodies, Monoclonal,
pubmed-meshheading:2933460-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2933460-Antigens, Surface,
pubmed-meshheading:2933460-Cell Movement,
pubmed-meshheading:2933460-Histocytochemistry,
pubmed-meshheading:2933460-Humans,
pubmed-meshheading:2933460-Immunoglobulin Idiotypes,
pubmed-meshheading:2933460-Lymphoma,
pubmed-meshheading:2933460-Mice,
pubmed-meshheading:2933460-Receptors, Immunologic,
pubmed-meshheading:2933460-Receptors, Interleukin-2,
pubmed-meshheading:2933460-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2933460-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2933460-T-Lymphocytes, Regulatory,
pubmed-meshheading:2933460-Tissue Distribution
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pubmed:year |
1985
|
pubmed:articleTitle |
Differences in "host infiltrates" among lymphoma patients treated with anti-idiotype antibodies: correlation with treatment response.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|