Linked Life Data

2933129

Source:http://linkedlifedata.com/resource/pubmed/id/2933129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-1-22
pubmed:abstractText
A family of peptides, known as atrial natriuretic factors (ANF), have been isolated from atrial muscle tissue and reported to have profound effects on water and salt metabolism. ANF have also been reported to be present in the brain. The primary actions of these peptides lead to a reduction in plasma and extracellular fluid volume by eliciting natriuresis and diuresis, and by opposing the action of other peptidergic systems such as the vasopressin and angiotensin systems that promote water retention and enhance drinking behavior. This study was designed to determine if, in addition to its peripheral actions, ANF would also affect water ingestion, a mechanism that would be consistent with its general actions as a factor regulating extracellular fluid volume. Intraventricular (IVT) administration of an ANF, atriopeptin III (APIII), to intact male rats resulted in a significant inhibition of water intake in animals which were conditioned to drink during a one hour period. The inhibitory effects of APIII were immediate and most effective during the first 15 minute period, when maximal drinking occurred. Most remarkably, APIII given IVT also inhibited the potent dipsogenic action of angiotensin II (AII) on both water and a 2% NaCl solution intake. The results strongly suggest that ANF may have a significant role in central regulation of fluid intake and that its antidipsogenic effects may be mediated, at least in part, by an inhibitory effect on the central action of AII.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
523-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Inhibition of spontaneous or angiotensin II-stimulated water intake by atrial natriuretic factor.
pubmed:publicationType
Journal Article