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rdf:type |
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lifeskim:mentions |
umls-concept:C0003842,
umls-concept:C0006684,
umls-concept:C0012472,
umls-concept:C0028127,
umls-concept:C0086418,
umls-concept:C0205409,
umls-concept:C0230972,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1704632,
umls-concept:C1705490,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
1986-1-9
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pubmed:abstractText |
Six point concentration-response curves were established for the contractile effect of prostaglandin E2 (PGE2) on helically-cut strips of human chorionic plate arteries. Tissues were then allocated to one of four treatment groups: a control group and 3 groups exposed to the calcium channel blocker nitrendipine at 10(-9), 10(-7) or 10(-5) M. The concentration-response curves were then repeated. The addition of nitrendipine was associated with a significant depression of the induced contraction. The contractile response to the lower doses of PGE2 was replaced by a small relaxation in 63% of the treated tissues. It is suggested that in these tissues PGE2 exerts its constrictor effect via the receptor-operated channels and that nitrendipine is blocking this effect. Similar experiments performed with PGE1 showed great variability in the initial response. Nitrendipine 10(-5) M failed to exert any detectable effect on this response. Pregnancy-induced hypertension is associated with vasoconstriction in both the maternal and placental circulations. There also appears to be a relative excess of vasoconstrictor eicosanoid production. Nitrendipine may be of use in the treatment of this condition.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-14274808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-16994996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-37533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-4625155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-507115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-5659062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-6102688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-6588754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-6794766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-6871553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-7073757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2933111-7258242
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
705-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2933111-Alprostadil,
pubmed-meshheading:2933111-Arteries,
pubmed-meshheading:2933111-Calcium Channel Blockers,
pubmed-meshheading:2933111-Cesarean Section,
pubmed-meshheading:2933111-Chorion,
pubmed-meshheading:2933111-Dinoprostone,
pubmed-meshheading:2933111-Female,
pubmed-meshheading:2933111-Humans,
pubmed-meshheading:2933111-Nifedipine,
pubmed-meshheading:2933111-Nitrendipine,
pubmed-meshheading:2933111-Pregnancy,
pubmed-meshheading:2933111-Prostaglandins E,
pubmed-meshheading:2933111-Random Allocation,
pubmed-meshheading:2933111-Vasoconstriction
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pubmed:year |
1985
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pubmed:articleTitle |
The effect of a calcium antagonist, nitrendipine, on the responses of isolated strips of human, chorionic plate artery to prostaglandins E2 and E1.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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