Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-10-30
pubmed:abstractText
Simultaneous numerical and functional studies of circulatory lymphocytes were undertaken in healthy non-smoking and cigarette-smoking volunteers. The smokers all had light to moderate histories of less than 50 pack years. By contrast with non-smokers (n = 32), the smokers (n = 14) had a significant increase in the total number of lymphocytes, surface immunoglobulin bearing (sIg+) cells, total T-cells (T3+) and T helper-inducer cells (T4+), and a trend of increase in T suppressor-cytotoxic cells (8+). These changes differ from those in heavy smokers who have been reported to show significantly increased T suppressor-cytotoxic but significantly decreased T helper-inducer cells. Although the proportions of T-cell subsets did not differ significantly in the light to moderate smokers compared with non-smokers, in vitro T-suppressor function against the Ig-secreting response of allogeneic B-cells to pokeweed mitogen (PWM) stimulation was significantly impaired. The proliferative response of T-cells to phytohaemagglutinin (PHA) was, however, similar in both groups. This suggests that smoking may exert a selective influence upon a subset of T suppressor cells. In cytotoxicity assays, smokers showed a significant decrease in natural killer cell (NK) activity but not in antibody dependent cellular cytotoxicity (ADCC). It appears that these alterations are reversible since a group of ex-smokers (n = 10) were indistinguishable from our non-smoking group in all studies. The implications regarding the link between smoking and increased susceptibility to infection and malignancy are discussed; and these findings should be borne in mind in basic studies of lymphocytes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-1009386, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-1082401, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-305005, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-314668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-315435, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-457307, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-4594699, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-4688852, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-5356947, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6154658, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6213706, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6444652, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6446683, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6633406, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6790658, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6966400, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6980611, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6982152, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-711506, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-7127903, http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-7377637
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
459-66
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Numerical and functional alterations in circulatory lymphocytes in cigarette smokers.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't