rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-10-30
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pubmed:abstractText |
Simultaneous numerical and functional studies of circulatory lymphocytes were undertaken in healthy non-smoking and cigarette-smoking volunteers. The smokers all had light to moderate histories of less than 50 pack years. By contrast with non-smokers (n = 32), the smokers (n = 14) had a significant increase in the total number of lymphocytes, surface immunoglobulin bearing (sIg+) cells, total T-cells (T3+) and T helper-inducer cells (T4+), and a trend of increase in T suppressor-cytotoxic cells (8+). These changes differ from those in heavy smokers who have been reported to show significantly increased T suppressor-cytotoxic but significantly decreased T helper-inducer cells. Although the proportions of T-cell subsets did not differ significantly in the light to moderate smokers compared with non-smokers, in vitro T-suppressor function against the Ig-secreting response of allogeneic B-cells to pokeweed mitogen (PWM) stimulation was significantly impaired. The proliferative response of T-cells to phytohaemagglutinin (PHA) was, however, similar in both groups. This suggests that smoking may exert a selective influence upon a subset of T suppressor cells. In cytotoxicity assays, smokers showed a significant decrease in natural killer cell (NK) activity but not in antibody dependent cellular cytotoxicity (ADCC). It appears that these alterations are reversible since a group of ex-smokers (n = 10) were indistinguishable from our non-smoking group in all studies. The implications regarding the link between smoking and increased susceptibility to infection and malignancy are discussed; and these findings should be borne in mind in basic studies of lymphocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-1009386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-1082401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-305005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-314668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-315435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-457307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-4594699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-4688852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-5356947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6154658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6213706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6444652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6446683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6633406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6790658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6966400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6980611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-6982152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-711506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-7127903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2931227-7377637
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9104
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-66
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2931227-Adult,
pubmed-meshheading:2931227-Antibodies, Monoclonal,
pubmed-meshheading:2931227-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:2931227-Concanavalin A,
pubmed-meshheading:2931227-Cytotoxicity, Immunologic,
pubmed-meshheading:2931227-Female,
pubmed-meshheading:2931227-Humans,
pubmed-meshheading:2931227-Killer Cells, Natural,
pubmed-meshheading:2931227-Leukocyte Count,
pubmed-meshheading:2931227-Lymphocytes,
pubmed-meshheading:2931227-Male,
pubmed-meshheading:2931227-Middle Aged,
pubmed-meshheading:2931227-Receptors, Antigen, B-Cell,
pubmed-meshheading:2931227-Smoking,
pubmed-meshheading:2931227-T-Lymphocytes,
pubmed-meshheading:2931227-T-Lymphocytes, Regulatory
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pubmed:year |
1985
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pubmed:articleTitle |
Numerical and functional alterations in circulatory lymphocytes in cigarette smokers.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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