2930707

Source:http://linkedlifedata.com/resource/pubmed/id/2930707

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004083, umls-concept:C0023884, umls-concept:C0027651, umls-concept:C0205054, umls-concept:C0232338, umls-concept:C0439165, umls-concept:C0549193, umls-concept:C0559956
pubmed:issue	3
pubmed:dateCreated	1989-5-23
pubmed:abstractText	The extent of hepatic replacement with tumour is a significant prognostic factor in patients with liver metastases. Measuring the percentage hepatic replacement (PHR) accurately is difficult, but is important for both patient management and clinical trial evaluation. This study correlates haemodynamic indices obtained by dynamic liver scintigraphy (DLS) with estimates of PHR made from isotope scan, ultrasound, CT scan and laparotomy in 45 patients with established colorectal liver metastases and 21 controls who also underwent DLS. There was a significant reduction in the mesenteric fraction (MF) in the group of patients with metastases compared to the controls (P less than 0.001), and also a significant trend for progressive reduction in the MF with increasing PHR. A significant rise in an index of total hepatic arterial blood flow was also demonstrated with increasing PHR. These results are important with current interest in regional hepatic arterial therapy, and may prove of clinical value for prediction or monitoring of response to therapy.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-2647022, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-2931055, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-3567061, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-3675390, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-3696630, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-3724180, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-3971119, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-4050517, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-4272905, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-499220, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-5801146, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-6644371, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-7223955, http://linkedlifedata.com/resource/pubmed/commentcorrection/2930707-7452351
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370635
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0007-0920
pubmed:author	pubmed-author:BrittenA JAJ, pubmed-author:FlemingJ SJS, pubmed-author:FlowerdewA DAD, pubmed-author:HuntT MTM, pubmed-author:KarranS JSJ, pubmed-author:TaylorII
pubmed:issnType	Print
pubmed:volume	59
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	410-4
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:2930707-Colorectal Neoplasms, pubmed-meshheading:2930707-Humans, pubmed-meshheading:2930707-Liver, pubmed-meshheading:2930707-Liver Circulation, pubmed-meshheading:2930707-Liver Neoplasms, pubmed-meshheading:2930707-Prognosis, pubmed-meshheading:2930707-Splanchnic Circulation
pubmed:year	1989
pubmed:articleTitle	An association between parameters of liver blood flow and percentage hepatic replacement with tumour.
pubmed:affiliation	University Surgical Unit, Department of Nuclear Medicine, Southampton General Hospital, UK.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't