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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1989-4-28
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pubmed:abstractText |
Exposure of HeLa and HL60 cells to sodium arsenite or cadmium chloride led to marked increases in cellular heme oxygenase activity. SDS-polyacrylamide gel electrophoresis of [35S]methionine-labeled cellular proteins indicated that these treatments also resulted in the induction of a 32-kDa protein. Immunoblot analysis further showed that the 32-kDa protein reacted with anti-bovine heme oxygenase antibodies. Treatment of the cells with cobaltic chloride or heat induced neither the 32-kDa protein nor heme oxygenase activity. It is concluded that the 32-kDa stress protein induced by arsenite and cadmium ions in these human cells is heme oxygenase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anions,
http://linkedlifedata.com/resource/pubmed/chemical/Arsenic,
http://linkedlifedata.com/resource/pubmed/chemical/Arsenites,
http://linkedlifedata.com/resource/pubmed/chemical/Cadmium,
http://linkedlifedata.com/resource/pubmed/chemical/Cations,
http://linkedlifedata.com/resource/pubmed/chemical/Cobalt,
http://linkedlifedata.com/resource/pubmed/chemical/HMOX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/arsenite,
http://linkedlifedata.com/resource/pubmed/chemical/cobaltous chloride
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
245
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2924920-Anions,
pubmed-meshheading:2924920-Arsenic,
pubmed-meshheading:2924920-Arsenites,
pubmed-meshheading:2924920-Cadmium,
pubmed-meshheading:2924920-Cations,
pubmed-meshheading:2924920-Cobalt,
pubmed-meshheading:2924920-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:2924920-HeLa Cells,
pubmed-meshheading:2924920-Heat-Shock Proteins,
pubmed-meshheading:2924920-Heme Oxygenase (Decyclizing),
pubmed-meshheading:2924920-Heme Oxygenase-1,
pubmed-meshheading:2924920-Hot Temperature,
pubmed-meshheading:2924920-Humans,
pubmed-meshheading:2924920-Immunoblotting,
pubmed-meshheading:2924920-Leukemia,
pubmed-meshheading:2924920-Mixed Function Oxygenases,
pubmed-meshheading:2924920-Molecular Weight,
pubmed-meshheading:2924920-Tumor Cells, Cultured
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pubmed:year |
1989
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pubmed:articleTitle |
The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase.
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pubmed:affiliation |
Department of Hygiene, Kansai Medical University, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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