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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1989-4-13
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pubmed:abstractText |
Over eighty N-alkyl vancomycins were synthesized by reductive alkylation of vancomycin with the appropriate aldehydes. The N-alkyl vancomycins exhibit greater antibacterial activity than the corresponding N-acyl vancomycins and the parent antibiotic. Some of these semisynthetic vancomycins are five times more active than vancomycin. The N-alkyl vancomycins also show longer elimination half-lives in rats than vancomycin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-8820
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-72
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading | |
pubmed:year |
1989
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pubmed:articleTitle |
Synthesis and antibacterial evaluation of N-alkyl vancomycins.
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pubmed:affiliation |
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.
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pubmed:publicationType |
Journal Article
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