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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-4-13
|
| pubmed:abstractText |
The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
244
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
473-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2920840-Animals,
pubmed-meshheading:2920840-Arthritis, Rheumatoid,
pubmed-meshheading:2920840-Cells, Cultured,
pubmed-meshheading:2920840-Chick Embryo,
pubmed-meshheading:2920840-Collagen,
pubmed-meshheading:2920840-Humans,
pubmed-meshheading:2920840-Matrix Metalloproteinase 3,
pubmed-meshheading:2920840-Metalloendopeptidases,
pubmed-meshheading:2920840-Substrate Specificity,
pubmed-meshheading:2920840-Synovial Fluid
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells.
|
| pubmed:affiliation |
Department of Pathology, School of Medicine, Kanazawa University, Ishikawa, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|