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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1989-4-6
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pubmed:abstractText |
Radioiodinated benzoyl esters and amides of epimeric 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols were synthesized in an effort to find an agent that would be rapidly and selectively taken up by adrenal cortical tissue. Achievement of such a goal would provide a basis for the development of adrenal imaging agents superior to those currently available for clinical use. The iodobenzoyl derivatives were obtained by treating the appropriate epimer with 2-iodobenzoic acid in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine. The resulting esters and amides were readily labeled with radioiodine by isotope exchange with sodium iodide-125 in pivalic acid. Tissue distribution studies in female rats revealed that only the esters displayed appreciable adrenal specificity, and the ester having the same configuration at C-20 as cholesterol was significantly better than the corresponding C-20 epimer.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Iodobenzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnenolone
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2918507-Adrenal Cortex,
pubmed-meshheading:2918507-Amides,
pubmed-meshheading:2918507-Animals,
pubmed-meshheading:2918507-Esters,
pubmed-meshheading:2918507-Female,
pubmed-meshheading:2918507-Iodine Radioisotopes,
pubmed-meshheading:2918507-Iodobenzoates,
pubmed-meshheading:2918507-Isotope Labeling,
pubmed-meshheading:2918507-Pregnenolone,
pubmed-meshheading:2918507-Rats,
pubmed-meshheading:2918507-Rats, Inbred Strains,
pubmed-meshheading:2918507-Structure-Activity Relationship,
pubmed-meshheading:2918507-Tissue Distribution
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pubmed:year |
1989
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pubmed:articleTitle |
Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols.
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pubmed:affiliation |
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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