Linked Life Data

2917344

Source:http://linkedlifedata.com/resource/pubmed/id/2917344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-3-31
pubmed:abstractText
The effect of anatomical site of tumour growth on selective uptake and retention of chloro-aluminium sulphonated phthalocyanine (ClAlSPc) was determined using the murine colorectal carcinoma (Colo 26). Tumours were established in the liver, spleen, kidney, lung, thoracic cavity and s.c. flank region of syngeneic BALB/c mice and animals received 10 mg/kg ClAlSPc by i.v. injection. Colo 26 growths at s.c., intra-pulmonary, intra-thoracic or intra-renal sites took up and retained greater amounts of ClAlSPc than did adjacent normal tissues. Such selective retention of ClAlSPc by neoplastic tissue was not observed when Colo 26 was grown in the spleen, where tumour and normal tissue took up about the same amounts, or the liver, where normal tissue took up more ClAlSPc than either directly implanted or metastatic tumours. ClAlSPc ratios found in tumour/adjacent tissue may vary for a single tumour growing at different anatomical sites and such variability could have a distinct effect on the efficacy of photodynamic therapy of cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effect of tumour location on selective uptake and retention of phthalocyanines.
pubmed:affiliation
Biology of Metastasis Laboratory, Imperial Cancer Research Fund Laboratories, London, U.K.
pubmed:publicationType
Journal Article