Linked Life Data

2916325

Source:http://linkedlifedata.com/resource/pubmed/id/2916325

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-15
pubmed:abstractText
Persistent infection with lymphocytic choriomeningitis virus (LCMV) Armstrong strain in C3H/ST mice is associated with a growth hormone (GH) deficiency syndrome, characterized by growth retardation and low serum glucose levels (M.B.A. Oldstone et al., 1982, Science 218, 1125-1127). The syndrome is associated with a decrease in GH synthesis in the pituitary gland, in the absence of cellular injury in the pituitary or associated brain areas. In this report, we demonstrate that the decreases in steady-state synthesis of GH and its mRNA in virally infected mice is related to a 16-fold reduction in initiation of transcription of this gene. Minimal decrease, however, was demonstrated in transcriptional initiation of another pituitary gene, the precursor of thyroid simulating hormone (TSH-beta) or of the housekeeping genes, actin and pro alpha 2(I) collagen. Thus, viruses can cause disease in the absence of cytolytic or morphologic injury by selectively disrupting the synthesis of a differentiated cellular product at the level of transcriptional initiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
232-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Lymphocytic choriomeningitis virus selectively alters differentiated but not housekeeping functions: block in expression of growth hormone gene is at the level of transcriptional initiation.
pubmed:affiliation
Research Institute of Scripps Clinic, Department of Immunology, La Jolla, California 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't