Linked Life Data

2915796

Source:http://linkedlifedata.com/resource/pubmed/id/2915796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1989-3-23
pubmed:abstractText
Previous studies showed that few foci of cerebro-cortical microdysgenesis (molecular layer neuronal ectopias and focal laminar dysplasia) are present in up to 26% of variably processed normal brains; they are more common in the right inferior frontal region. Brains of male developmental dyslexics processed in serial histologic sections showed 30 to 140 foci of these types of anomalies, predominantly in left perisylvian cortex. Here, we present the results of a detailed analysis of ten normal brains also processed in serial sections. The ages ranged from 3.5 to 87 years, all male. Three brains showed abnormalities similar in type to those of the dyslexic, but in far smaller numbers and in different locations: two showed a single cingulate focus--one right, one left; the third brain showed two right supratemporal foci. We conclude that the present form of developmental anomaly is rare in normal brains, and that the findings in the dyslexic brains may be significant.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-3878
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Cerebrocortical microdysgenesis in neurologically normal subjects: a histopathologic study.
pubmed:affiliation
Dyslexia Neuroanatomical Laboratory, Beth Israel Hospital, Boston, MA 02215.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't