rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-3-17
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pubmed:abstractText |
Bovine adrenal medullary cells released significant amounts of opioid pentapeptides Met- and Leu-enkephalin and catecholamines, when stimulated by neurotensin (NT). Maximal release induced by this peptide was about 40-50% of that seen after nicotinic activation of cholinergic receptors. Dose-response curves for neurotensin-induced secretion revealed an EC50 of 1x10(-6)M, thereby being in the range of that for acetylcholine or nicotine. Secretory effects were dependent on extracellular Ca++ and impaired by the Ca++ channel blocker D 600. Moreover NT produced an increase in opioid peptide cell content after 48 and 72 hrs of incubation. Besides affecting opioid peptide metabolism, NT significantly produced accumulation of inositol- 1-phosphates (IP1), the significance of which remains to be clarified in the observed metabolic effects.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0024-3205
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
44
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
327-35
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2915604-Adrenal Medulla,
pubmed-meshheading:2915604-Animals,
pubmed-meshheading:2915604-Cattle,
pubmed-meshheading:2915604-Cells, Cultured,
pubmed-meshheading:2915604-Enkephalin, Leucine,
pubmed-meshheading:2915604-Enkephalin, Methionine,
pubmed-meshheading:2915604-Enkephalins,
pubmed-meshheading:2915604-Inositol Phosphates,
pubmed-meshheading:2915604-Neurotensin,
pubmed-meshheading:2915604-Norepinephrine,
pubmed-meshheading:2915604-Sugar Phosphates
|
pubmed:year |
1989
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pubmed:articleTitle |
Neurotensin affects metabolism of opioid peptides, catecholamines and inositol phospholipids in bovine chromaffin cells.
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pubmed:affiliation |
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Martinsried, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article
|