Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-3-17
pubmed:abstractText
Bovine adrenal medullary cells released significant amounts of opioid pentapeptides Met- and Leu-enkephalin and catecholamines, when stimulated by neurotensin (NT). Maximal release induced by this peptide was about 40-50% of that seen after nicotinic activation of cholinergic receptors. Dose-response curves for neurotensin-induced secretion revealed an EC50 of 1x10(-6)M, thereby being in the range of that for acetylcholine or nicotine. Secretory effects were dependent on extracellular Ca++ and impaired by the Ca++ channel blocker D 600. Moreover NT produced an increase in opioid peptide cell content after 48 and 72 hrs of incubation. Besides affecting opioid peptide metabolism, NT significantly produced accumulation of inositol- 1-phosphates (IP1), the significance of which remains to be clarified in the observed metabolic effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-35
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Neurotensin affects metabolism of opioid peptides, catecholamines and inositol phospholipids in bovine chromaffin cells.
pubmed:affiliation
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Martinsried, Federal Republic of Germany.
pubmed:publicationType
Journal Article