Linked Life Data

2912088

Source:http://linkedlifedata.com/resource/pubmed/id/2912088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-2-23
pubmed:abstractText
In baboons, the placenta remains in situ and functional with respect to the potential for aromatization after removal of the fetus (fetectomy). Fetectomy therefore was used to study effects of the fetus and estrogen on placental delivery. By term, serum estradiol levels in untreated, intact baboons had increased to 4 to 8 ng/ml, and fetoplacental delivery occurred on day 184 +/- 1 (mean +/- SE). Fetectomy at midgestation resulted in a nondetectable serum estradiol level and a marked decline in progesterone level; however, placentas were maintained in situ and were delivered on day 171 +/- 6. After fetectomy therefore the initiation of placental delivery and, presumably, myometrial contractility did not require an elevation in estrogen. Administration of estradiol (1 to 10 mg/day) to baboons after fetectomy resulted in normal serum estradiol concentrations, but placental delivery was prevented. When estrogen was discontinued on days 215 to 250, the serum estradiol level declined, and placental delivery occurred on day 262 +/- 18, a value greater than in intact baboons or untreated baboons after fetectomy (p less than 0.001). Thus estrogen prevented placental delivery in baboons after fetectomy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-41
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The effect of estrogen on placental delivery after fetectomy in baboons.
pubmed:affiliation
Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore 21201.
pubmed:publicationType
Journal Article