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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1979-12-18
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pubmed:abstractText |
Moloney murine sarcoma virus (MSV) virions incubated under optimal conditions were shown to support extensive synthesis of double-stranded DNA. The major product, a 5950-base-pair (6-kilobase-pair DNA) double-stranded DNA, was characterized by cleavage with restriction endonucleases and shown to contain a 600-nucleotide-long direct repeat at both ends of the MSV genome. Linear DNA molecules made in vivo shortly after infection were compared to the linear double-stranded DNA synthesized in vitro. The restriction maps of both viral DNA products were indistinguishable. The 600-base-pair repeat results in a progeny DNA molecule that is longer than the parental MSV genomic RNA. The generation of this repeat must involve a mechanism that allows the viral reverse transcriptase (RNA-dependent DNA nucleotidyltransferase) to copy 5'- and 3'-terminal genomic (+) strand sequences twice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-184965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-189494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-197259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-205652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-207898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-208071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-209213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-209450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-212592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-215324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-215325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-215781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-219216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-264682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-353301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-4355528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-455438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-4935105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-657274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-66683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-66684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-71657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-77733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-845942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-84715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/291003-88264
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3294-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
Moloney murine sarcoma virions synthesize full-genome-length double-stranded DNA in vitro.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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