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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-2-6
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pubmed:abstractText |
A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparable to that of mitomycin C. The X-ray-determined crystal structure of one of the derivatives (3f) is reported.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
248-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2909738-Animals,
pubmed-meshheading:2909738-Antibiotics, Antineoplastic,
pubmed-meshheading:2909738-Chemical Phenomena,
pubmed-meshheading:2909738-Chemistry,
pubmed-meshheading:2909738-Leukemia P388,
pubmed-meshheading:2909738-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2909738-Mice,
pubmed-meshheading:2909738-Mitomycins,
pubmed-meshheading:2909738-Models, Molecular,
pubmed-meshheading:2909738-Structure-Activity Relationship
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pubmed:year |
1989
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pubmed:articleTitle |
Mitomycin C analogues with a substituted hydrazine at position 7. Synthesis, spectral properties, and biological activity.
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pubmed:affiliation |
Department of Chemistry, University of Houston, Texas 77204-5641.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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