Linked Life Data

2909359

Source:http://linkedlifedata.com/resource/pubmed/id/2909359

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-2-1
pubmed:abstractText
In view of recent evidence that changes in phospholipid components of pulmonary surfactant occur in bleomycin-induced pulmonary fibrosis, the aim of this study was to examine whether similar changes occur in patients with idiopathic pulmonary fibrosis. We have analyzed phospholipid profiles in bronchoalveolar lavage (BAL) fluids from a group of 32 patients with "lone" cryptogenic fibrosing alveolitis (CFA) compared with 17 control subjects. Prior to treatment, resembling the findings in bleomycin fibrosis, many CFA patients had decreased proportions of phosphatidylglycerol (PG) (percent of total phospholipid; median 10.5, range 0 to 35.1 compared with 18.2, range 9.6 to 24.2 for the control group of similar age range and smoking habits; p less than 0.01). Following the initial lavage, the patients were treated with prednisolone. The initial percentage of PG levels did not predict response to prednisolone, but serial lavage studies conducted in 14 patients suggest that an early and sustained increase in percentage of PG following commencement of prednisolone is associated with clinical improvement. The reasons for the proportional reductions in phosphatidylglycerol, and whether they result in functional deficiency of surfactant in CFA, need to be explored.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0012-3692
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
82-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Changes in phosphatidylglycerol in bronchoalveolar lavage fluids from patients with cryptogenic fibrosing alveolitis.
pubmed:affiliation
Cell Biology Unit, Cardiothoracic Institute, London, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't