Linked Life Data

2906127

Source:http://linkedlifedata.com/resource/pubmed/id/2906127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1276
pubmed:dateCreated
1989-3-21
pubmed:abstractText
The possible involvement of adenosine diphosphate (ADP) in haemostatic platelet aggregation was investigated by determining the duration of primary haemorrhage as standardized bleeding times from punctures of small mesenteric arteries in anaesthetized rats. The bleeding times were highly significantly increased by infusing into the mesenteric arterial blood flowing towards the punctures either the nucleotide-dephosphorylating enzyme apyrase or the ADP-receptor antagonists ATP, adenosine 5'-(beta,gamma-methylene)triphosphonate (AMP-PCP) or 2-methylthioadenosine 5'-(beta,gamma-methylene)triphosphonate (2-MeS-AMP-PCP). The increases in bleeding times could not be accounted for by local vasodilator effects of the agents. It is concluded that the presence of ADP through local release and/or formation at sites of vascular injury contributes significantly to haemostasis, presumably by accelerating platelet aggregation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0080-4649
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-62
pubmed:dateRevised
2007-4-30
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Evidence for the dependence of arterial haemostasis on ADP.
pubmed:affiliation
Department of Pharmacology, King's College London, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't