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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0020522,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021745,
umls-concept:C0026809,
umls-concept:C0035820,
umls-concept:C0205263,
umls-concept:C0205463,
umls-concept:C0332120,
umls-concept:C0597357,
umls-concept:C1332714,
umls-concept:C1334114,
umls-concept:C1423842,
umls-concept:C1515021
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|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1989-3-14
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|
pubmed:abstractText |
In mice, induction of delayed-type hypersensitivity (DTH) and of antibody formation to sheep red blood cells (SRBC) was inhibited by the anti-CD4 monoclonal antibody (mAb) GK1.5. However, anti-interleukin 2 mAb AMT-13 inhibited DTH response but not antibody formation. The inhibitory action of the mAb on DTH, but not an antibody formation, was reversed by concomitant injection of recombinant mouse interferon-gamma. These data provide the first in vivo evidence for the postulated physiological role of the CD4+ TH1 lymphocyte subset and indicate that the action of anti-interleukin 2 receptor mAb is restricted to this T helper subset.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-2980
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
18
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2101-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2905998-Animals,
pubmed-meshheading:2905998-Antibodies, Monoclonal,
pubmed-meshheading:2905998-Antigen-Antibody Reactions,
pubmed-meshheading:2905998-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2905998-CD4-Positive T-Lymphocytes,
pubmed-meshheading:2905998-Hypersensitivity, Delayed,
pubmed-meshheading:2905998-Interferon-gamma,
pubmed-meshheading:2905998-Interleukin-2,
pubmed-meshheading:2905998-Mice,
pubmed-meshheading:2905998-Receptors, Interleukin-2,
pubmed-meshheading:2905998-T-Lymphocytes, Helper-Inducer
|
|
pubmed:year |
1988
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|
pubmed:articleTitle |
Reversal by interferon-gamma of inhibition of delayed-type hypersensitivity induction by anti-CD4 or anti-interleukin 2 receptor (CD25) monoclonal antibodies. Evidence for the physiological role of the CD4+ TH1+ subset in mice.
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pubmed:affiliation |
Institut für Immunologie, Klinikum Steglitz, Freie Universität Berlin.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
