Linked Life Data

2905600

Source:http://linkedlifedata.com/resource/pubmed/id/2905600

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pubmed-article:2905600pubmed:abstractTextA Japanese group comprising 53 hyperlipidemic and 54 normolipidemic subjects was genotyped for DNA restriction fragment length polymorphisms (RFLPs) at the apo B gene locus. The polymorphisms with XbaI and PvuII were present at allelic frequencies of 0.04 (X1 allele) and 0.96 (X2 allele), 0.94 (P1 allele) and 0.06 (P2 allele), respectively. Unlike the previous reported association of the X1 allele with hypercholesterolemia found in Caucasians there was no difference in the frequency of the X1 allele between normolipidemic and hypercholesterolemic Japanese. Among the Japanese, two RFLPs appear to be in linkage equilibrium and can be used in conjunction as a haplotype. There is no strong population association in our patient group between any allele of the RFLPs studied and hyperlipidemia.lld:pubmed
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pubmed-article:2905600pubmed:articleTitleA study of DNA polymorphism in the apolipoprotein B gene in a Japanese population.lld:pubmed
pubmed-article:2905600pubmed:affiliationThird Department of Internal Medicine, University of Tokyo, Japan.lld:pubmed
pubmed-article:2905600pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2905600pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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