Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-2-22
pubmed:abstractText
A Japanese group comprising 53 hyperlipidemic and 54 normolipidemic subjects was genotyped for DNA restriction fragment length polymorphisms (RFLPs) at the apo B gene locus. The polymorphisms with XbaI and PvuII were present at allelic frequencies of 0.04 (X1 allele) and 0.96 (X2 allele), 0.94 (P1 allele) and 0.06 (P2 allele), respectively. Unlike the previous reported association of the X1 allele with hypercholesterolemia found in Caucasians there was no difference in the frequency of the X1 allele between normolipidemic and hypercholesterolemic Japanese. Among the Japanese, two RFLPs appear to be in linkage equilibrium and can be used in conjunction as a haplotype. There is no strong population association in our patient group between any allele of the RFLPs studied and hyperlipidemia.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-6
pubmed:dateRevised
2008-8-19
pubmed:meshHeading
pubmed-meshheading:2905600-Adult, pubmed-meshheading:2905600-Aged, pubmed-meshheading:2905600-Alleles, pubmed-meshheading:2905600-Apolipoproteins B, pubmed-meshheading:2905600-Cholesterol, pubmed-meshheading:2905600-DNA, pubmed-meshheading:2905600-Deoxyribonucleases, Type II Site-Specific, pubmed-meshheading:2905600-Female, pubmed-meshheading:2905600-Gene Frequency, pubmed-meshheading:2905600-Genes, pubmed-meshheading:2905600-Genotype, pubmed-meshheading:2905600-Humans, pubmed-meshheading:2905600-Hyperlipidemias, pubmed-meshheading:2905600-Japan, pubmed-meshheading:2905600-Male, pubmed-meshheading:2905600-Middle Aged, pubmed-meshheading:2905600-Polymorphism, Genetic, pubmed-meshheading:2905600-Polymorphism, Restriction Fragment Length, pubmed-meshheading:2905600-Reference Values, pubmed-meshheading:2905600-Triglycerides
pubmed:year
1988
pubmed:articleTitle
A study of DNA polymorphism in the apolipoprotein B gene in a Japanese population.
pubmed:affiliation
Third Department of Internal Medicine, University of Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't