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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-2-8
|
| pubmed:abstractText |
We report the identification and characterization of two restriction fragment polymorphisms (RFLPs) associated with the human c-raf-1 protooncogene located on chromosome 3 (3p25). EcoRI digestion produces an RFLP derived from the 5'flanking sequences with a heterozygosity of 28%, and TaqI produces an RFLP representing the 3' flanking sequences with a heterozygosity of 25%. The finding of RFLPs associated with a potential oncogene may provide a method of analysis for determining genetic susceptibilities to certain cancers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0890-6467
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
99-103
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:2905034-Chromosome Mapping,
pubmed-meshheading:2905034-Chromosomes, Human, Pair 3,
pubmed-meshheading:2905034-Humans,
pubmed-meshheading:2905034-Polymorphism, Genetic,
pubmed-meshheading:2905034-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2905034-Proto-Oncogene Proteins,
pubmed-meshheading:2905034-Proto-Oncogene Proteins c-raf
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
DNA restriction fragment length polymorphisms at either end of the c-raf-1 locus at 3p25.
|
| pubmed:affiliation |
Department of Medicine, SUNY-Health Science Center, Syracuse 13210.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|