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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1989-1-18
|
| pubmed:abstractText |
A high incidence of luteal phase defect (LPD) has been reported using subcutaneous pulsatile gonadotropin-releasing hormone for induction of ovulation. We reviewed all patients treated with the combination of subcutaneous pulsatile gonadotropin-releasing hormone during the follicular phase and human chorionic gonadotropin during the luteal phase (GnRH-hCG) who underwent endometrial biopsy during a treatment cycle. All of these patients had biopsy-proven LPD which persisted despite traditional therapy with progesterone vaginal suppositories and/or clomiphene citrate. The mean number of biopsies out of phase per patient prior to GnRH-hCG treatment was 2.8 +/- 0.2 (+/- SEM). When treated with GnRH-hCG, 15/16 patients (94%) showed a normal endometrial biopsy. The probability of this result occurring by chance alone allowing for a 50% treatment independent correction rate is less than .001. These results show that the combination of subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin can result in normal endometrial maturation in a high percentage of cycles when administered as described. It appears to be an effective alternative to traditional treatment modalities for luteal phase defect should one be needed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0020-725X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
329-33
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2904419-Biopsy, Needle,
pubmed-meshheading:2904419-Chorionic Gonadotropin,
pubmed-meshheading:2904419-Endometrium,
pubmed-meshheading:2904419-Female,
pubmed-meshheading:2904419-Follicular Phase,
pubmed-meshheading:2904419-Humans,
pubmed-meshheading:2904419-Infusion Pumps,
pubmed-meshheading:2904419-Injections, Subcutaneous,
pubmed-meshheading:2904419-Luteal Phase,
pubmed-meshheading:2904419-Luteolysis,
pubmed-meshheading:2904419-Pituitary Hormone-Releasing Hormones,
pubmed-meshheading:2904419-Retrospective Studies
|
| pubmed:articleTitle |
Endometrial biopsies during treatment with subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin.
|
| pubmed:affiliation |
University of Minnesota Medical School, Department of Obstetrics and Gynecology, Minneapolis.
|
| pubmed:publicationType |
Journal Article
|