Linked Life Data

2904387

Source:http://linkedlifedata.com/resource/pubmed/id/2904387

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-1-17
pubmed:abstractText
We have cloned the murine glutamine synthetase (GS) gene and measured GS enzyme activity and mRNA in five tissues (retina, brain, liver, kidney, and skeletal muscle) during perinatal development. Retinal GS enzyme activity increases 200-fold between Day 1 and Day 21 and is accompanied by an increase in the level of GS mRNA; developmental regulation in other tissues is much less dramatic. Based on Southern blotting analysis, a single GS gene gives rise to the tissue-specific patterns of GS mRNA expression. The increase in murine retinal GS observed during perinatal development is similar in magnitude to that observed in the chicken retina just prior to hatching. In the embryonic chicken retina, glucocorticoid hormones mediate a large increase in the level of GS mRNA. However, although glucocorticoids induce a 12-fold increase in GS mRNA in murine skeletal muscle, expression of the retinal enzyme and mRNA is only modestly glucocorticoid-inducible in the mouse. Therefore, despite the hormonal responsiveness of the murine GS gene, it is not likely that glucocorticoids are important physiological modulators of the developmental rise in murine retinal GS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
536-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Murine glutamine synthetase: cloning, developmental regulation, and glucocorticoid inducibility.
pubmed:affiliation
Department of Chemistry, University of Illinois, Chicago 60680.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't