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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-1-23
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pubmed:abstractText |
By use of in situ hybridization experiments, the mouse homeobox genes Hox-3.1 and Hox-1.5 are compared in the temporal and spatial patterns of their embryonic transcripts. Transcripts of both genes are first detected at about 7 1/2 days, although the appearance of Hox-3.1 transcripts apparently follows Hox-1.5 after a small delay. Hox-3.1 and Hox-1.5 transcripts occupy domains which are different, although overlapping, along the anteroposterior axis of the embryo. The domains are first established within the ectoderm and mesoderm germ layers at 7 1/2-8 days, but subsequently they persist within the nervous system, the prevertebral column and within at least some of the organs (the thyroid, lung, stomach, mesonephric and metanephric kidneys) at 12 1/2 days. In discussion, two different mechanisms are considered by which positional information might first be generated within the germ layers.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0950-1991
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-44
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2904354-Animals,
pubmed-meshheading:2904354-Autoradiography,
pubmed-meshheading:2904354-Embryo, Mammalian,
pubmed-meshheading:2904354-Embryonic and Fetal Development,
pubmed-meshheading:2904354-Gene Expression Regulation,
pubmed-meshheading:2904354-Genes, Homeobox,
pubmed-meshheading:2904354-Mice,
pubmed-meshheading:2904354-Morphogenesis,
pubmed-meshheading:2904354-Time Factors,
pubmed-meshheading:2904354-Transcription, Genetic
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pubmed:year |
1988
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pubmed:articleTitle |
Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5.
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pubmed:affiliation |
Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK.
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pubmed:publicationType |
Journal Article
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