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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1988-11-22
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pubmed:abstractText |
The regulatory function of peripheral blood CD4 T cells correlates with the presence or absence of the membrane glycoprotein recognized by anti-Leu-8 antibody; CD4,Leu8- T cells help Ig synthesis and CD4,Leu-8+ T cells suppress Ig synthesis. In contrast to CD4 T cells from the peripheral blood and organized gut-associated lymphoid tissues, intestinal lamina propria CD4 T cells were found to have diminished expression of the Leu-8 Ag. Therefore, studies were performed to determine whether the decreased expression of the Leu-8 Ag on lamina propria CD4 T cells correlates with a difference in the ability of peripheral blood and lamina propria CD4 T cells to regulate PWM-stimulated Ig synthesis. At high T cell to non-T cell ratios, the helper function of lamina propria CD4 T cells was significantly higher than that of peripheral blood CD4 T cells. When CD4 T cells were incubated with anti-Leu-8 antibody, the suppressor function of peripheral blood CD4 T cells was increased, but lamina propria CD4 T cells did not suppress Ig synthesis. No difference was found between the helper function of CD4,Leu-8- T cells and the suppressor function of CD4, Leu-8+ T cells isolated from either the peripheral blood or the lamina propria. Thus, the difference in the regulatory function of CD4 T cells from the peripheral blood and the lamina propria is due to the quantitative difference in CD4,Leu-8+ T cells in these sites. Consequently, the intestinal lamina propria is a site enriched in CD4,Leu-8- T cells which predominantly mediate help for Ig synthesis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3029-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2902143-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2902143-Appendix,
pubmed-meshheading:2902143-Cell-Free System,
pubmed-meshheading:2902143-Cells, Cultured,
pubmed-meshheading:2902143-Humans,
pubmed-meshheading:2902143-Immunoglobulins,
pubmed-meshheading:2902143-Immunosuppressive Agents,
pubmed-meshheading:2902143-Intestinal Mucosa,
pubmed-meshheading:2902143-Lymph Nodes,
pubmed-meshheading:2902143-Lymphocyte Activation,
pubmed-meshheading:2902143-Mesentery,
pubmed-meshheading:2902143-Phenotype,
pubmed-meshheading:2902143-Pokeweed Mitogens,
pubmed-meshheading:2902143-T-Lymphocytes,
pubmed-meshheading:2902143-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2902143-T-Lymphocytes, Regulatory
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pubmed:year |
1988
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pubmed:articleTitle |
CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria.
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pubmed:affiliation |
Mucosal Immunity Section, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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