| pubmed-article:2901431 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C0001075 | lld:lifeskim |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C0376180 | lld:lifeskim |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C1335871 | lld:lifeskim |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C1882911 | lld:lifeskim |
| pubmed-article:2901431 | lifeskim:mentions | umls-concept:C0293352 | lld:lifeskim |
| pubmed-article:2901431 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2901431 | pubmed:dateCreated | 1988-10-26 | lld:pubmed |
| pubmed-article:2901431 | pubmed:abstractText | Gastric acid exerts a feedback inhibition on the secretion of gastrin from antral G cells. This study examines whether gastrin gene expression is also regulated by changes in gastric pH. Achlorhydria was induced in rats by the gastric H+/K+ ATPase inhibitor, omeprazole (100 mumol/kg). This resulted in fourfold increases in both serum gastrin (within 2 h) and gastrin mRNA levels (after 24 h). Antral somatostatin D cells probably act as chemoreceptors for gastric acid to mediate a paracrine inhibition on gastrin secretion from adjacent G cells. Omeprazole-induced achlorhydria reduced D-cell activity as shown by a threefold decrease in antral somatostatin mRNA levels that began after 24 h. Exogenous administration of the somatostatin analogue SMS 201-995 (10 micrograms/kg) prevented both the hypergastrinemia and the increase in gastrin mRNA levels caused by omeprazole-induced achlorhydria. Exogenous somatostatin, however, did not influence the decrease in antral somatostatin mRNA levels seen with achlorhydria. These data, therefore, support the hypothesis that antral D cells act as chemoreceptors for changes in gastric pH, and modulates somatostatin secretion and synthesis to mediate a paracrine inhibition on gastrin gene expression in adjacent G cells. | lld:pubmed |
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| pubmed-article:2901431 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2901431 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2901431 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2901431 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2901431 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2901431 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2901431 | pubmed:author | pubmed-author:StoneDD | lld:pubmed |
| pubmed-article:2901431 | pubmed:author | pubmed-author:BrandS JSJ | lld:pubmed |
| pubmed-article:2901431 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2901431 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2901431 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2901431 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2901431 | pubmed:pagination | 1059-66 | lld:pubmed |
| pubmed-article:2901431 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2901431 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2901431 | pubmed:articleTitle | Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. | lld:pubmed |
| pubmed-article:2901431 | pubmed:affiliation | Department of Medicine, Harvard Medical School, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:2901431 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2901431 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2901431 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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