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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-10-26
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pubmed:abstractText |
Gastric acid exerts a feedback inhibition on the secretion of gastrin from antral G cells. This study examines whether gastrin gene expression is also regulated by changes in gastric pH. Achlorhydria was induced in rats by the gastric H+/K+ ATPase inhibitor, omeprazole (100 mumol/kg). This resulted in fourfold increases in both serum gastrin (within 2 h) and gastrin mRNA levels (after 24 h). Antral somatostatin D cells probably act as chemoreceptors for gastric acid to mediate a paracrine inhibition on gastrin secretion from adjacent G cells. Omeprazole-induced achlorhydria reduced D-cell activity as shown by a threefold decrease in antral somatostatin mRNA levels that began after 24 h. Exogenous administration of the somatostatin analogue SMS 201-995 (10 micrograms/kg) prevented both the hypergastrinemia and the increase in gastrin mRNA levels caused by omeprazole-induced achlorhydria. Exogenous somatostatin, however, did not influence the decrease in antral somatostatin mRNA levels seen with achlorhydria. These data, therefore, support the hypothesis that antral D cells act as chemoreceptors for changes in gastric pH, and modulates somatostatin secretion and synthesis to mediate a paracrine inhibition on gastrin gene expression in adjacent G cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-229955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-236515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-2858817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-2863938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-2868965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-2873074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-2878856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-2881850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-3453895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-3510144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-382360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-4139406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-4639640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-5411129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-580834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6128648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6133871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6145584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6194404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6198133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6316340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6490654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-690183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-6941282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-7096324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-7359441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2901431-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1059-66
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2901431-Achlorhydria,
pubmed-meshheading:2901431-Animals,
pubmed-meshheading:2901431-Gastrins,
pubmed-meshheading:2901431-Gene Expression Regulation,
pubmed-meshheading:2901431-Male,
pubmed-meshheading:2901431-Omeprazole,
pubmed-meshheading:2901431-Pyloric Antrum,
pubmed-meshheading:2901431-RNA, Messenger,
pubmed-meshheading:2901431-Rats,
pubmed-meshheading:2901431-Rats, Inbred Strains,
pubmed-meshheading:2901431-Somatostatin
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pubmed:year |
1988
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pubmed:articleTitle |
Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria.
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pubmed:affiliation |
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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