Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-9-20
pubmed:abstractText
Previous karyotypic analysis of human small cell lung cancer cell lines has demonstrated a consistent deletion of a portion of the short arm of chromosome 3(p14-23). DNA prepared from tumors and normal tissues obtained from 24 small cell lung cancer and two extrapulmonary small cell cancer patients was hybridized to four probes that detect restriction fragment length polymorphisms within chromosome region 3p14-21. Of the 25 patients who were heterozygous for at least one marker in this region in the DNA from normal tissue, 23 (92%) showed an unequivocal loss of heterozygosity in the DNA from their tumor tissue. From these studies we conclude that loss of alleles from the short arm of chromosome 3 is a consistent finding in unselected small cell lung cancer patients' tumor DNA.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-14114111, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-163140, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-208044, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-2821400, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-2885753, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-2982478, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-2985257, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3010709, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3010710, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3031816, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3032033, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3034978, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3486416, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3536362, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-3720360, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-470981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-5387828, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6095990, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6133281, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6198090, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-626181, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6273747, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6274023, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6286098, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6320640, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6325937, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6325938, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6325939, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6327578, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6336308, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6336310, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6585809, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6585826, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6633649, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6694706, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-6823558, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-7112106, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-7273954, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-7280668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2900253-7375916
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
502-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors.
pubmed:affiliation
National Cancer Institute-Navy Medical Oncology Branch, Bethesda, Maryland 20814.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't