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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1988-9-21
|
| pubmed:abstractText |
The effects of regional alpha- and specific beta 2-adrenergic receptor blockade on measurements of late diastolic coronary resistance (LDCR) and mean coronary blood flow velocity (CBFV) during exercise were examined in 14 conscious adult mongrel dogs. Specific beta 2-adrenergic receptor blockade (ICI 118.551) significantly decreased CBFV and increased LDCR by blockade of beta 2-vasodilator tone independent of alpha-adrenergic receptor-mediated tone and independent of altering myocardial metabolism. alpha-Adrenergic receptor blockade (phentolamine, 1 mg) significantly increased CBFV and decreased LDCR by blocking sympathetically mediated vasoconstrictor tone. There was no significant difference in the magnitude of response between alpha- and beta 2-adrenergic receptor blockade. These results demonstrate that alpha- and beta 2-adrenergic receptors have a significant and evidently equal influence on CBFV and LDCR during exercise. Four weeks of daily exercise and left stellate ganglionectomy (LSGx) prevented phentolamine-induced vasodilation but not ICI 118.551-induced vasoconstriction. This suggests that daily exercise and LSGx significantly decreased the alpha-adrenergic receptor-mediated vasoconstrictor tone on the coronary circulation, resulting in an apparently greater role for the coronary vascular beta 2-adrenergic receptor on the control of CBFV and LDCR during exercise.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/ICI 118551,
http://linkedlifedata.com/resource/pubmed/chemical/Phentolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2287-93
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2900233-Adrenergic beta-Antagonists,
pubmed-meshheading:2900233-Animals,
pubmed-meshheading:2900233-Blood Pressure,
pubmed-meshheading:2900233-Coronary Circulation,
pubmed-meshheading:2900233-Diastole,
pubmed-meshheading:2900233-Dogs,
pubmed-meshheading:2900233-Heart Rate,
pubmed-meshheading:2900233-Myocardial Contraction,
pubmed-meshheading:2900233-Myocardium,
pubmed-meshheading:2900233-Oxygen Consumption,
pubmed-meshheading:2900233-Phentolamine,
pubmed-meshheading:2900233-Physical Exertion,
pubmed-meshheading:2900233-Propanolamines,
pubmed-meshheading:2900233-Receptors, Adrenergic, beta,
pubmed-meshheading:2900233-Reference Values,
pubmed-meshheading:2900233-Regional Blood Flow,
pubmed-meshheading:2900233-Stellate Ganglion,
pubmed-meshheading:2900233-Vascular Resistance
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Role of beta 2-adrenergic receptors on coronary resistance during exercise.
|
| pubmed:affiliation |
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|