| pubmed-article:2900044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2900044 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2900044 | lifeskim:mentions | umls-concept:C0020291 | lld:lifeskim |
| pubmed-article:2900044 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:2900044 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:2900044 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:2900044 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:2900044 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2900044 | pubmed:dateCreated | 1988-9-15 | lld:pubmed |
| pubmed-article:2900044 | pubmed:abstractText | Astrocyte-enriched primary cultures of newborn rat brain hemispheres, prelabeled with [3H]inositol, accumulated [3H]inositol phosphate but not [3H]inositol bis- and tris-phosphate, after exposure to histamine for 60 min in the presence of 10 mM LiCl. The response to histamine was not a function of contaminating meningeal fibroblasts since no accumulation of [3H]inositol phosphate was elicited by histamine in meningeal cultures. The stimulation of phosphoinositide hydrolysis by histamine in astrocytes was dose-dependent (EC50 = 1.7 microM, maximal effect = 345% over basal levels) and was mimicked by several H1-receptor agonists. The use of selective receptor antagonists confirmed that the histamine response was the result of activation of H1-receptors. The histamine-induced [3H]inositol phosphate accumulation was completely abolished by omission of Ca2+ from the incubation medium. Astrocyte membranes specifically bound the radiolabeled H1-antagonist, [3H]mepyramine with an affinity (Kd = 5.9 nM) and a density of binding sites (Bmax = 113 fmol/mg protein) similar to rat brain. These results demonstrate the presence of functional histamine H1-receptors in rat brain astrocytes and suggest a role for histamine as a neuromodulator of astrocyte function. | lld:pubmed |
| pubmed-article:2900044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2900044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2900044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2900044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2900044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2900044 | pubmed:month | May | lld:pubmed |
| pubmed-article:2900044 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2900044 | pubmed:author | pubmed-author:PicatosteFF | lld:pubmed |
| pubmed-article:2900044 | pubmed:author | pubmed-author:GarcíaAA | lld:pubmed |
| pubmed-article:2900044 | pubmed:author | pubmed-author:ArbonésLL | lld:pubmed |
| pubmed-article:2900044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2900044 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:2900044 | pubmed:volume | 450 | lld:pubmed |
| pubmed-article:2900044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2900044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2900044 | pubmed:pagination | 144-52 | lld:pubmed |
| pubmed-article:2900044 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2900044 | pubmed:meshHeading | pubmed-meshheading:2900044-... | lld:pubmed |
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| pubmed-article:2900044 | pubmed:meshHeading | pubmed-meshheading:2900044-... | lld:pubmed |
| pubmed-article:2900044 | pubmed:meshHeading | pubmed-meshheading:2900044-... | lld:pubmed |
| pubmed-article:2900044 | pubmed:meshHeading | pubmed-meshheading:2900044-... | lld:pubmed |
| pubmed-article:2900044 | pubmed:meshHeading | pubmed-meshheading:2900044-... | lld:pubmed |
| pubmed-article:2900044 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2900044 | pubmed:articleTitle | Histamine H1-receptors mediate phosphoinositide hydrolysis in astrocyte-enriched primary cultures. | lld:pubmed |
| pubmed-article:2900044 | pubmed:affiliation | Instituto de Biología Fundamental Vincent Villar Palasi, Universidad Autónoma de Barcelona, Bellaterra, Spain. | lld:pubmed |
| pubmed-article:2900044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2900044 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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