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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4866
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pubmed:dateCreated |
1988-9-8
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pubmed:abstractText |
The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-carboxypiperazin-4-yl)propyl-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ibotenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Amino-3-hydroxy-5-methyl-4-iso...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
241
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
701-3
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:2899909-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:2899909-Action Potentials,
pubmed-meshheading:2899909-Animals,
pubmed-meshheading:2899909-Aspartic Acid,
pubmed-meshheading:2899909-Binding, Competitive,
pubmed-meshheading:2899909-Cell Membrane,
pubmed-meshheading:2899909-Cerebral Cortex,
pubmed-meshheading:2899909-Ibotenic Acid,
pubmed-meshheading:2899909-Kainic Acid,
pubmed-meshheading:2899909-Ketamine,
pubmed-meshheading:2899909-N-Methylaspartate,
pubmed-meshheading:2899909-Neurons,
pubmed-meshheading:2899909-Piperazines,
pubmed-meshheading:2899909-Quinoxalines,
pubmed-meshheading:2899909-Rats,
pubmed-meshheading:2899909-Receptors, AMPA,
pubmed-meshheading:2899909-Receptors, Drug,
pubmed-meshheading:2899909-Receptors, Glutamate,
pubmed-meshheading:2899909-Receptors, Kainic Acid,
pubmed-meshheading:2899909-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:2899909-Receptors, Neurotransmitter,
pubmed-meshheading:2899909-Spinal Cord,
pubmed-meshheading:2899909-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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pubmed:year |
1988
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pubmed:articleTitle |
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
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pubmed:affiliation |
Ferroson Research Division, Soeborg, Denmark.
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pubmed:publicationType |
Journal Article,
Comparative Study
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