Linked Life Data

2899005

Source:http://linkedlifedata.com/resource/pubmed/id/2899005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-8-12
pubmed:abstractText
1. The effects of histamine on cholinergic nerve transmission were investigated in the oesophagus of the chick (0-29 days old). 2. Histamine potentiated the contractile responses produced by vagal or transmural nerve stimulation and by the ganglionic stimulant (DMPP) with the increase of tonus of oesophagus. On the other hand, a selective H2 agonist, 4-methylhistamine, did not have any effect. 3. The sensitivity of oesophagus to ACh did not change in the presence of histamine (0.2-2 microM). 4. Mepyramine but not metiamide antagonized the contractile and potentiating effects of histamine. 5. From these findings, it is concluded that histamine preferentially acts on H1-receptors located in cholinergic neurones to facilitate cholinergic transmission in the chick oesophagus, potentiating the nerve-mediated contraction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0742-8413
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-6
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Histamine-induced potentiation of cholinergic transmission in chick oesophagus (Gallus gallus).
pubmed:affiliation
Department of Veterinary Pharmacology, Faculty of Dairy Science, Rakuno Gakuen University, Ebetsu, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't