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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3-4
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pubmed:dateCreated |
1988-8-8
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pubmed:abstractText |
The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0001-6489
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2898860-Adrenergic alpha-Agonists,
pubmed-meshheading:2898860-Animals,
pubmed-meshheading:2898860-Carotid Artery, External,
pubmed-meshheading:2898860-Female,
pubmed-meshheading:2898860-Imidazoles,
pubmed-meshheading:2898860-Lasers,
pubmed-meshheading:2898860-Ligation,
pubmed-meshheading:2898860-Male,
pubmed-meshheading:2898860-Maxillary Sinus,
pubmed-meshheading:2898860-Mucociliary Clearance,
pubmed-meshheading:2898860-Mucous Membrane,
pubmed-meshheading:2898860-Phenylpropanolamine,
pubmed-meshheading:2898860-Rabbits,
pubmed-meshheading:2898860-Regional Blood Flow,
pubmed-meshheading:2898860-Rheology
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pubmed:articleTitle |
Relations between blood flow and mucociliary activity in the rabbit maxillary sinus.
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pubmed:affiliation |
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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