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pubmed-article:2898843pubmed:abstractTextMutants of Vibrio cholerae defective in intestinal colonization have been constructed. Characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called TCP. The tcp operon has been cloned and strains of V. cholerae have been constructed that overproduce this pilus and the B subunit of cholera toxin. Together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines.lld:pubmed
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pubmed-article:2898843pubmed:articleTitleSafe, live Vibrio cholerae vaccines?lld:pubmed
pubmed-article:2898843pubmed:affiliationDepartment of Microbiology and Immunology, University of Tennessee, Memphis 38163.lld:pubmed
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