Linked Life Data

2898695

Source:http://linkedlifedata.com/resource/pubmed/id/2898695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8602
pubmed:dateCreated
1988-8-11
pubmed:abstractText
Whether matching for HLA antigen "splits" results in better transplant outcome than matching for "broad" HLA antigens was investigated in 30,000 first cadaver kidney transplants. At three years, there was an 18% difference between the survival rates of grafts with 0 or 4 mismatches among transplants typed for HLA-A and B antigen splits whereas the difference in transplants typed for broad antigens was only 2%. Analysis of HLA-A, B antigens together with HLA-DR antigens showed an even greater advantage of matching for antigen splits: the difference in survival at three years between grafts with 0 or 6 mismatches for HLA-A, B, DR was 31% when antigen splits were analysed, in contrast to a 6% difference with broad antigens. These results indicate that typing for HLA antigen splits is important in renal transplantation, that the potential benefit of HLA matching in renal transplantation is greater than currently accepted, and that HLA typing and kidney allocation routines must be refined in order to exploit this potential.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Importance of HLA antigen splits for kidney transplant matching.
pubmed:affiliation
Department of Transplantation Immunology, University of Heidelberg, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't