Linked Life Data

2897800

Source:http://linkedlifedata.com/resource/pubmed/id/2897800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 1
pubmed:dateCreated
1988-7-8
pubmed:abstractText
Using a full-length rat intrinsic factor (IF) cDNA clone, we have examined gene expression of IF in selected tissues from the adult rat and during postnatal development in the rat stomach. IF mRNA was expressed only in the rat stomach, and in situ hybridization revealed that the expression was limited to the chief cells at the base of the oxyntic glands. IF mRNA concentration in the stomach increased with postnatal age and reached a peak at the 30th day. Postnatally the amount of IF mRNA hybridized increased in both individual cells and in total number of cells. Administration of cortisol to, or adrenalectomy of, rats between 5 and 12 days of age resulted in increase or decrease of IF mRNA levels, respectively. Other hormones tested (pentagastrin, thyroxine, and triiodothyronine) had no significant effect. During the suckling period, IF bound well to the ileal receptor, despite lower than adult levels of activity and different glycosylation, as assessed by binding to concanavalin A-Sepharose beads. These results show that developmental expression of IF activity in rat is closely related to the expression of its mRNA and that corticosteroids play an important role in such an expression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G913-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Developmental regulation of rat intrinsic factor mRNA.
pubmed:affiliation
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't