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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8597
|
| pubmed:dateCreated |
1988-7-11
|
| pubmed:abstractText |
To evaluate the effectiveness of immune serum globulin (ISG) in preventing non-A, non-B hepatitis, 291 heart surgery patients who received blood from voluntary donors were randomly assigned to receive either ISG or no additional protection. ISG was given intramuscularly before and 1 week after transfusion. 98 controls and 100 in the ISG group completed the study. Post-transfusion non-A, non-B hepatitis developed in 11 (11.2%) controls but in only 3 (3.0%) of the ISG group (p = 0.0203). 8 (72.7%) of control group with hepatitis had symptoms, and in 5 (45.4%) the disease became chronic. The disease was self-limiting in all 3 ISG patients affected, and only 1 of them had symptoms. Among those with non-A, non-B hepatitis aminotransferase levels were higher in the controls than in the ISG patients. Incubation periods longer than 8 weeks correlated with a tendency for the disease to become chronic. ISG recipients had shorter as well as more homogeneous incubation periods. ISG could be a safe, low-cost means for preventing post-transfusion non-A, non-B hepatitis which does not call for the discarding of donated blood.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1245-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2897517-Adolescent,
pubmed-meshheading:2897517-Adult,
pubmed-meshheading:2897517-Aged,
pubmed-meshheading:2897517-Blood Transfusion,
pubmed-meshheading:2897517-Cardiac Surgical Procedures,
pubmed-meshheading:2897517-Child,
pubmed-meshheading:2897517-Clinical Trials as Topic,
pubmed-meshheading:2897517-Evaluation Studies as Topic,
pubmed-meshheading:2897517-Female,
pubmed-meshheading:2897517-Follow-Up Studies,
pubmed-meshheading:2897517-Hepatitis,
pubmed-meshheading:2897517-Hepatitis, Chronic,
pubmed-meshheading:2897517-Hepatitis, Viral, Human,
pubmed-meshheading:2897517-Hepatitis B,
pubmed-meshheading:2897517-Hepatitis C,
pubmed-meshheading:2897517-Humans,
pubmed-meshheading:2897517-Immunization, Passive,
pubmed-meshheading:2897517-Injections, Intramuscular,
pubmed-meshheading:2897517-Male,
pubmed-meshheading:2897517-Middle Aged,
pubmed-meshheading:2897517-Random Allocation,
pubmed-meshheading:2897517-Time Factors
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Prevention of post-transfusion non-A, non-B hepatitis by non-specific immunoglobulin in heart surgery patients.
|
| pubmed:affiliation |
Department of Internal Medicine, Virgen del Rocío Hospital, Seville, Spain.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Case Reports,
Research Support, Non-U.S. Gov't
|