|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1988-6-30
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|
pubmed:abstractText |
Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-3573
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pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
40
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
144-6
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
|
|
pubmed:year |
1988
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|
pubmed:articleTitle |
Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain.
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|
pubmed:affiliation |
Istituto di Chimica Farmaceutica e Tossicologica, Università di Roma, Italy.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
