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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1988-6-20
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pubmed:abstractText |
The restriction fragment length polymorphism technique, employing seven restriction endonucleases, and a DR-specific repeated element probe were used to study a large panel of homozygous typing cells in order to delineate haplotypic differences within the HLA-DRw52 supertype. Most of the restriction endonucleases revealed the presence of two allelic restriction fragment length polymorphisms correlating with and splitting the HLA-DRw52 supertypic specificity. One designated A, correlated with the HLA-DRw52 typing in HLA-DR5, HLA-DR3, (non-A1, B8), and some HLA-DRw6 haplotypes. The other, designated a, correlated with the HLA-DRw52 typing in HLA-DR5, HLA-DRw8, HLA-DR3 (A1, B8), and the remaining HLA-DRw6 haplotypes. The general applicability of these findings was validated in 47 HLA-typed laboratory controls.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0198-8859
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-97
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2896651-Alleles,
pubmed-meshheading:2896651-HLA-D Antigens,
pubmed-meshheading:2896651-HLA-DR Antigens,
pubmed-meshheading:2896651-HLA-DR Serological Subtypes,
pubmed-meshheading:2896651-Haplotypes,
pubmed-meshheading:2896651-Humans,
pubmed-meshheading:2896651-Polymorphism, Genetic,
pubmed-meshheading:2896651-Polymorphism, Restriction Fragment Length
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pubmed:year |
1988
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pubmed:articleTitle |
Restriction fragment length polymorphisms and an HLA-DRw52-associated split.
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pubmed:affiliation |
Department of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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