Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1988-4-11
|
pubmed:abstractText |
Human T-lymphotropic virus type I (HTLV-I), the etiological agent of adult T-cell leukemia/lymphoma, also appears to be the cause of tropical spastic paraparesis, a chronic myelopathy reported in several different regions of the world. The prevalence of antibodies to HTLV-I in patients with chronic neurodegenerative disorders other than tropical spastic paraparesis and in patients with some muscle inflammatory disorders has been investigated. IgG antibodies to HTLV-I were measured in the sera and/or cerebrospinal fluid from 82 Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia, 164 Guamanian normal controls, 10 patients with kuru from the Eastern Highlands of Papua New Guinea, 4 patients with Viliuisk encephalomyelitis from the Iakut region of eastern Siberia, 45 Italian patients with multiple sclerosis, and 56 patients with polymyositis (49 from the United States and 7 from Jamaica). As determined by enzyme-linked immunosorbent assay, Western immunoblot, and gelatin particle agglutination techniques, serological evidence of HTLV-I infection was found in 1 patient with amyotrophic lateral sclerosis and 1 control subject from Guam, and in 1 patient from the United States and all 7 Jamaican patients with polymyositis. Except for the high seropositivity rate among the group of Jamaican patients with polymyositis, our data indicate that HTLV-I is an unlikely causative agent in the spectrum of the neurological diseases examined. The seropositivity of the 7 Jamaican patients with polymyositis requires further study.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0364-5134
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
23 Suppl
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
S192-5
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:2894813-Adult,
pubmed-meshheading:2894813-Aged,
pubmed-meshheading:2894813-Aged, 80 and over,
pubmed-meshheading:2894813-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:2894813-Antibodies, Viral,
pubmed-meshheading:2894813-Chronic Disease,
pubmed-meshheading:2894813-Deltaretrovirus Antibodies,
pubmed-meshheading:2894813-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2894813-Humans,
pubmed-meshheading:2894813-Middle Aged,
pubmed-meshheading:2894813-Muscle Spasticity,
pubmed-meshheading:2894813-Nervous System Diseases,
pubmed-meshheading:2894813-Paraplegia,
pubmed-meshheading:2894813-Parkinson Disease,
pubmed-meshheading:2894813-Tropical Climate
|
pubmed:year |
1988
|
pubmed:articleTitle |
Seroprevalence of antibodies to HTLV-I in patients with chronic neurological disorders other than tropical spastic paraparesis.
|
pubmed:affiliation |
Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
|
pubmed:publicationType |
Journal Article
|