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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-4-19
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pubmed:abstractText |
Bordetella pertussis extract that contained adenylate cyclase toxin produced large increases in human neutrophil cyclic AMP levels and inhibited their oxidative burst, as reflected by luminol-enhanced chemiluminescence and superoxide release. The adenylate cyclase toxin-containing extract blocked neutrophil-mediated inhibition of N-acetylglucosamine incorporation by arthroconidia of Coccidioides immitis in a dose-dependent fashion but had no effect on neutrophil phagocytosis of Candida glabrata and only a slight inhibitory effect on arthroconidial attachment. Neither purified pertussis toxin nor extracts from Bordetella mutants lacking the adenylate cyclase toxin affected neutrophil-mediated inhibition of arthroconidial N-acetylglucosamine incorporation. These studies indicate that adenylate cyclase toxin, alone or in concert with other B. pertussis-elaborated toxins, blocks neutrophil inhibition of arthroconidia, primarily by affecting neutrophil responses other than attachment or phagocytosis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-13295674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-180060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-184530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-2859287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-2867778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-2872107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-2878884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-2888823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-2989409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-3157993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-319171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-340470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-3857605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-3944479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-4131281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-4182532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-4364409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6088394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6088647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6094010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6140011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6141934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6209272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6253447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6287574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6292103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6293544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6301374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6311749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-6715897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-7086205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-7430646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2894360-959944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
751-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2894360-Acetylglucosamine,
pubmed-meshheading:2894360-Adenylate Cyclase,
pubmed-meshheading:2894360-Adenylate Cyclase Toxin,
pubmed-meshheading:2894360-Bacterial Toxins,
pubmed-meshheading:2894360-Blood Bactericidal Activity,
pubmed-meshheading:2894360-Bordetella pertussis,
pubmed-meshheading:2894360-Coccidioides,
pubmed-meshheading:2894360-Cyclic AMP,
pubmed-meshheading:2894360-Humans,
pubmed-meshheading:2894360-Neutrophils,
pubmed-meshheading:2894360-Oxygen Consumption,
pubmed-meshheading:2894360-Pertussis Toxin,
pubmed-meshheading:2894360-Phagocytosis,
pubmed-meshheading:2894360-Superoxides,
pubmed-meshheading:2894360-Virulence Factors, Bordetella
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pubmed:year |
1988
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pubmed:articleTitle |
Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus.
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pubmed:affiliation |
Department of Internal Medicine, University of Arizona College of Medicine, Tucson 85724.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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