Linked Life Data

2894254

Source:http://linkedlifedata.com/resource/pubmed/id/2894254

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-4-12
pubmed:abstractText
A proportion of Pgp-1+ cells in the thymus have been shown to have progenitor activity. In adult AKR/Cum mice the total Pgp-1+ population in the thymus differs from that of the bulk of thymocytes and is antigenically heterogeneous when examined by flow cytometry. Pgp-1+ thymocytes are enriched for several minor cell populations compared to total thymocytes: B2A2-, interleukin-2-receptor+ (IL-2R+), and Lyt-2-, L3T4-. However, these subsets are still a minor proportion of the Pgp-1+ cells, the majority being Lyt-2+ and/or L3T4+ and B2A2+. Pgp-1+ thymocytes also differ from the bulk of thymocytes in having lower amounts of Thy-1 and in showing a higher proportion of single positive (Lyt-2+, L3T4- or Lyt-2-, L3T4+) cells. Populations of adult thymocytes that are enriched in progenitor cells can be isolated by cytotoxic depletion using either anti-Thy-1 antibody (Thy-1 depletion) or anti-Lyt-2 and anti-L3T4 antibody (Lyt-2, L3T4 depletion). Pgp-1+ cells in progenitor cell-enriched populations are also phenotypically heterogeneous. Pgp-1+ cells in both populations may be IL-2R+ or IL-2R- and B2A2+ or B2A2-. The population of Pgp-1+ cells in progenitor cell-enriched populations in the adult differs from that of the fetus at 14 days of gestation in that in the 14-day fetus, most Pgp-1+ cells are IL-2R+. By Day 15 of gestation, distinct populations of Pgp-1+, IL-2R-; Pgp-1+, IL-2R+; and Pgp-1-, IL-2R+ cells are observed. In the 15-day fetus, as in the adult, many Pgp-1+ thymocytes express low to moderate levels of Thy-1. The total percentage of Pgp-1+ cells in the thymus varies among different mouse strains, ranging from 4 to 35% in the thymus of young adult mice. Pgp 1.1 strains contain more detectably Pgp-1+ thymocytes than Pgp 1.2 strains; however, there is variability in the proportion of Pgp-1+ cells, even among Pgp 1.2 strains. In contrast to AKR/Cum mice, the Pgp-1+ thymocyte population in BALB/c mice, which contain a high proportion of Pgp-1+ thymocytes, closely resembles the total thymocyte population.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-54
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:2894254-Animals, pubmed-meshheading:2894254-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:2894254-Antigens, Ly, pubmed-meshheading:2894254-Antigens, Surface, pubmed-meshheading:2894254-Antigens, Thy-1, pubmed-meshheading:2894254-Cell Separation, pubmed-meshheading:2894254-Cell Survival, pubmed-meshheading:2894254-Female, pubmed-meshheading:2894254-Gestational Age, pubmed-meshheading:2894254-Leukocyte Count, pubmed-meshheading:2894254-Membrane Glycoproteins, pubmed-meshheading:2894254-Mice, pubmed-meshheading:2894254-Mice, Inbred AKR, pubmed-meshheading:2894254-Mice, Inbred BALB C, pubmed-meshheading:2894254-Mice, Inbred C57BL, pubmed-meshheading:2894254-Phenotype, pubmed-meshheading:2894254-Pregnancy, pubmed-meshheading:2894254-Receptors, Lymphocyte Homing, pubmed-meshheading:2894254-Stem Cells, pubmed-meshheading:2894254-T-Lymphocytes
pubmed:year
1988
pubmed:articleTitle
Qualitative and quantitative heterogeneity in Pgp-1 expression among murine thymocytes.
pubmed:affiliation
Department of Cancer Biology, Salk Institute, San Diego, California 92138.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.