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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-4-11
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pubmed:abstractText |
17-Cyclopropylmethyl-3,14-dihydroxy-4,5-alpha-epoxy-6-beta-fluoromorp hinan (cycloFOXY) is a fluorinated derivative of naltrexone suitable for labeling opiate receptors using positron emission transaxial tomography. Using the quantitative ligand binding method "binding surface analysis," in vitro autoradiography, and site-directed alkylating agents, [3H]cycloFOXY is shown to label mu and kappa opiate binding sites in vitro. Similar results were obtained using [3H]naloxone. Additional experiments demonstrate that [3H]cycloFOXY administered in vivo also labels mu and kappa binding sites. The relevance of these findings are discussed from clinical and basic science perspectives.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-acetyl-6-deoxy-6-fluoronaltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/dynorphin (1-8),
http://linkedlifedata.com/resource/pubmed/chemical/naloxone receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-3223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
435-58
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2894229-Animals,
pubmed-meshheading:2894229-Autoradiography,
pubmed-meshheading:2894229-Brain,
pubmed-meshheading:2894229-Dynorphins,
pubmed-meshheading:2894229-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:2894229-Enkephalins,
pubmed-meshheading:2894229-Male,
pubmed-meshheading:2894229-Naloxone,
pubmed-meshheading:2894229-Naltrexone,
pubmed-meshheading:2894229-Peptide Fragments,
pubmed-meshheading:2894229-Rats,
pubmed-meshheading:2894229-Rats, Inbred Strains,
pubmed-meshheading:2894229-Receptors, Opioid,
pubmed-meshheading:2894229-Receptors, Opioid, delta,
pubmed-meshheading:2894229-Receptors, Opioid, kappa,
pubmed-meshheading:2894229-Receptors, Opioid, mu,
pubmed-meshheading:2894229-Synaptic Membranes,
pubmed-meshheading:2894229-Tomography, Emission-Computed
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pubmed:year |
1988
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pubmed:articleTitle |
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
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pubmed:affiliation |
Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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