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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-3-9
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pubmed:abstractText |
By using only reverse-phase h.p.l.c., three fragments of prosomatostatin were isolated from an extract of a human pancreatic neuroendocrine tumour that produced somatostatin, vasoactive intestinal polypeptide and gastrin-releasing peptide. The amino acid composition of the peptides indicated that they represented prosomatostatin-(1-63)-peptide, prosomatostain-(65-76)-peptide and prosomatostatin-(79-92)-peptide (somatostatin-14). The identity of prosomatostatin-(1-63)-peptide was confirmed by characterization of the products of digestion with Armillaria mellea (honey fungus) proteinase. Partial micro-sequencing of prosomatostatin-(1-63)-peptide showed that the Gly24-Ala25 bond of preprosomatostatin was the site of cleavage of the signal peptide. Thus human prosomatostatin is a protein of 92 amino acid residues that is proteolytically cleaved in a pancreatic tumour at the site of a dibasic-residue (arginine-lysine) processing site and at a single-monobasic-residue (arginine) processing site.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-1239277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-158032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-23849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-2409227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-2862993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-2865169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-3013708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-321960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-3516723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-3545904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-377080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-4359620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6105026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6108968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6126875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6133871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6137494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6138818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6142531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6149000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6151529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6370932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-6635661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-66472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-680597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2893603-7033368
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
248
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2893603-Amino Acids,
pubmed-meshheading:2893603-Chromatography, High Pressure Liquid,
pubmed-meshheading:2893603-Endopeptidases,
pubmed-meshheading:2893603-Humans,
pubmed-meshheading:2893603-Male,
pubmed-meshheading:2893603-Middle Aged,
pubmed-meshheading:2893603-Pancreatic Neoplasms,
pubmed-meshheading:2893603-Peptide Fragments,
pubmed-meshheading:2893603-Protein Precursors,
pubmed-meshheading:2893603-Somatostatin
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pubmed:year |
1987
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pubmed:articleTitle |
Characterization of three peptides derived from prosomatostatin [prosomatostatin-(1-63)-, -(65-76)- and -(79-92)-peptides] in a human pancreatic tumour.
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pubmed:affiliation |
Clinical Research Group for Gastrointestinal Endocrinology, Max Planck Society, University of Göttingen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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