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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-3-2
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pubmed:abstractText |
The alpha-spectrin locus (SPTA) on chromosome 1 maps to 1q22-q25 and alpha-spectrin specific probes detect restriction fragment length polymorphisms (RFLPs) with the endonucleases MspI and PvuII. The Duffy blood group (FY) has been mapped to the 1p21-q23 region. We found positive linkage between the alpha-spectrin and the Duffy loci with a maximal Lod score of 3.81 at theta = 0.0 using the computer program MLINK. This indicates that both loci are very closely linked and probably localized to 1q22-q23.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0340-6717
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
76-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2892777-Blood Group Antigens,
pubmed-meshheading:2892777-Charcot-Marie-Tooth Disease,
pubmed-meshheading:2892777-Chromosome Mapping,
pubmed-meshheading:2892777-Duffy Blood-Group System,
pubmed-meshheading:2892777-Female,
pubmed-meshheading:2892777-Genes, Dominant,
pubmed-meshheading:2892777-Genetic Linkage,
pubmed-meshheading:2892777-Genetic Markers,
pubmed-meshheading:2892777-Humans,
pubmed-meshheading:2892777-Male,
pubmed-meshheading:2892777-Muscular Atrophy, Spinal,
pubmed-meshheading:2892777-Pedigree,
pubmed-meshheading:2892777-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2892777-Spectrin
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pubmed:year |
1988
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pubmed:articleTitle |
The Duffy blood group is linked to the alpha-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1.
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pubmed:affiliation |
Department of Biochemistry, University of Antwerp UIA, WiLrijk, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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