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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-3-2
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pubmed:abstractText |
Genomic hybridization analysis has been used to investigate allelic frequencies of the genes coding for the four major apoproteins of high density lipoprotein (HDL); apoproteins AI, AII, CII and CIII, in a group of Caucasian subjects with primary gout. An uncommon allelic variant of the apoprotein CIII gene (the S2 allele) was significantly more common among the patients with gout (9/48, 19%) than among normouricaemic controls who were either randomly selected (1/41, 2%, P = 0.03) or normotriglyceidaemic (0/33, 0%, P = 0.013). Approximately 46% (22/48) of the subjects with gout were hypertriglyceridaemic (with a serum triglyceride greater than 2.1 mmol/l). Of the 22 patients in this subgroup, 5 (23%) had the uncommon S1S2 genotype, which was also a significantly greater proportion than among the normotriglyceridaemic controls (P = 0.015). These data suggest that the hypertriglyceridaemia associated with primary gout may have a genetic basis. In contrast, we found no differences in the frequencies of restriction fragment length polymorphisms of the genes for apoproteins AI, AII and CII.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0340-6717
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-9
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:2892776-Apoproteins,
pubmed-meshheading:2892776-DNA,
pubmed-meshheading:2892776-Gene Frequency,
pubmed-meshheading:2892776-Genotype,
pubmed-meshheading:2892776-Gout,
pubmed-meshheading:2892776-Humans,
pubmed-meshheading:2892776-Middle Aged,
pubmed-meshheading:2892776-Polymorphism, Genetic,
pubmed-meshheading:2892776-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2892776-Triglycerides
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pubmed:year |
1988
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pubmed:articleTitle |
A DNA polymorphism of an apoprotein gene associates with the hypertriglyceridaemia of primary gout.
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pubmed:affiliation |
Department of Lipid Research, St. Bartholomew's Hospital, West Smithfield, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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