Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
1988-2-20
pubmed:abstractText
By a molecular genetic approach using polymorphic DNA markers that detect allelic deletion of specific chromosomal regions, we analyzed for possible loss of chromosomal heterozygosity in five different histological types of lung cancers obtained from 47 patients. In small-cell carcinomas, the incidence of allelic deletions at three different chromosomal loci was extremely high; loss of heterozygosity was detected on chromosomes 3p in 7 of 7 patients (100%), 13q in 10 of 11 patients (91%), and 17p in 5 of 5 patients (100%). The deletions at these loci in small-cell carcinomas were observed even in the tumors without any clinical evidence of metastasis. Furthermore, loss of heterozygosity on chromosomes 3p and 13q occurred prior to NMYC amplification and chromosome 11p deletion. Loss of heterozygosity on chromosome 3p was also detected with high frequency in adenocarcinomas [5 of 6 patients (83%)]. Heterozygosity of chromosomes 13q and 17p was lost in 10 of 31 patients (32%) and in 3 of 12 patients (25%), respectively, of lung cancers other than small-cell carcinomas. These results indicate that recessive genetic changes involving sequences on chromosomes 3p, 13q, and 17p may play important roles in the genesis of small-cell carcinoma, and those on chromosome 3p may play an important role in the genesis of adenocarcinoma.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2877398, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2885753, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2885916, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2991766, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2994066, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2997622, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-2999610, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3006911, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3031679, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3034409, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3092103, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3459165, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3823889, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3941898, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-3983638, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6133281, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6198090, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6274023, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6286098, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6325936, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6325937, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6325938, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6325939, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6633649, http://linkedlifedata.com/resource/pubmed/commentcorrection/2892196-6646201
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9252-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.
pubmed:affiliation
National Cancer Center Research Institute, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't